Bruce Donald: Fighting Cancer with Algorithms

Bruce Donald: Fighting Cancer with Algorithms

Bruce Donald, James B. Duke Distinguished Professor of Computer Science and professor in biochemistry and colleagues developed RESISTOR, an algorithm that uses protein structure-based computational design to predict how mutations in enzymes will affect a drug’s efficacy, especially when treating cancer. Cancer tumors often develop resistance to treatment, but this algorithm can predict those resistance mutations in advance, which could lead to better drug development and treatment plans.